The film, animated by Jellyfish Pictures, is written and directed by Academy Award nominee Phil Johnston (co-writer and co-director on Ralph Breaks the Internet, co-writer on Zootopia and Wreck-It Ralph) and will debut on Netflix on 17 October.

Joining the previously announced Johnny Vegas and Margo Martindale, who voice the eponymous Mr. & Mrs. Twits, as well as Emilia Clarke (Pippa) and Natalie Portman (Mary Muggle Wump) are Maitreyi Ramakrishnan (Beesha), Ryan Lopez (Bubsy), Timothy Simons (Marty Muggle-Wump), Nicole Byer (Beverly Onion), Jason Mantzoukas (Mayor Wayne John John-John), Alan Tudyk (Sweet Toed Toad), Mark Proksch (Horvis Dungle), Rebecca Wisocky (Dee Dumdie-Dungle), and Charlie Berens (Gorb Klurb).

The Twits marks the first screen adaptation inspired by the characters from the Roald Dahl book of the same name, which has been translated into 41 languages and sold 16 million copies worldwide.

Co-Directors are Katie Shanahan, Todd Demong, writers are Phil Johnston, Meg Favreau and it’s produced by Phil Johnston, Maggie Malone, Daisy May West

Phil Johnston said: “I still can’t quite believe that I spent the last few years collaborating with David Byrne, a musical hero of mine since I was 13. From the first demo he sent me, on which the featured instrument was a 100-year-old banjolele, I knew I was going to love the songs he wrote. Throughout the process, my collaboration with David has been incredibly fun and surprisingly easy, probably because I’ve been stealing from him for so long. When David and I started talking about an end credit song, the first potential collaborator David brought up was Hayley Williams. The first word I said was ‘yes.’ Followed by ‘please.’ I still can’t quite believe that two of my favorite songwriters wrote a song together for The Twits. The saying, ‘never meet your heroes’ simply does not apply here. I met two of them, and boy howdy, it’s been a dream come true.”